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Diseases

U

Ulcerative colitis (UC)

Inflammatory bowel disease (IBD) is the general term for a group of diseases of unknown etiology causing chronic inflammation or ulceration in the large or small intestine. In most cases, IBD signifies ulcerative colitis (UC) and Crohn's disease (CD). UC is characterized by inflammation in the innermost mucosal lining of the large intestine, causing erosions and ulcers. Symptoms typically include diarrhea, bloody stool, fever, abdominal pain, and weight loss.
Although the precise etiology of UC is unknown, it is thought to be related to abnormal immune system responses via autoimmune mechanisms. The immune system functions to exclude foreign substances from the body. When the immune mechanism malfunctions, for example, when it "recognizes" normal gastrointestinal bacteria as foreign, leukocytes are activated to release inflammatory cytokines, causing inflammation in the intestinal tract.
LCAP (leukocytapheresis) was developed as a therapy for inflammation in UC. It utilizes the Cellsorba leukocytapheresis filter in extracorporeal blood circulation to remove leukocytes responsible for inflammation from the peripheral blood. LCAP is a new therapeutic option for UC patients who do not or no longer benefit from conventional medications, or for patients who experience adverse effects from medications.

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Note: It might be required in your country that medical devices shall be officially registered and/or approved by an authorized organization. Please contact our representative in your region or contact us to confirm whether the listed products are approved for use. These information may contain general information on medical-related topics and is not meant to provide specialist advice or instructions concerning the products and services sold by Asahi Kasei Medical. Please contact us directly for special inquiries. You should not use this information for diagnosing a health problem or disease but should always consult your own physician.Contact us

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