Many studies have confirmed the efficacy of double filtration plasmapheresis (DFPP), immunoadsorption (IA), and plasma exchange (PE) in treating dermatologic diseases.

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Pemphigus
Pemphigoid

Pemphigus is an autoimmune dermatologic disease characterized by blistering of the skin and mucosa, often occurring in middle-aged or older people of both sexes. Pemphigoid is another autoimmune skin disease often observed in the elderly, characterized by skin blistering. Pemphigus and Pemphigoid are thought to result from serum autoantibodies directed against the epidermis, specifically keratinocytes in the surface layer.
Treatment for Pemphigus and Pemphigoid includes the administration of corticosteroids, immunosuppressants, and high-dose intravenous immunoglobulin (IVIg) and plasmapheresis. DFPP and PE remove autoantibodies to improve symptoms.

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Toxic epidermal necrolysis (TEN)

In toxic epidermal necrolysis (TEN), multiple large blisters form on the skin due to an allergic reaction to medication or infection. TEN occurs primarily in children and adolescents and the mortality rate is high. Treatment includes the administration of corticosteroids, high-dose IVIg and antibiotics, and plasmapheresis. DFPP and PE remove autoantibodies to improve symptoms.

Systemic sclerosis (SS)

Systemic sclerosis (SS) is a chronic connective tissue disease characterized by lesions in the skin, blood vessels, skeletal muscle, and internal organs. Treatment for SS includes the administration of aspirin, nonsteroidal antiinflammatory drugs (NSAIDs) and corticosteroids, and plasmaphersis. The etiology of SS is unknown. Recent studies have indicated that autoantibody, fibrosis, and blood vessel abnormalities are involved.