The high-flux Polysulfone APS from Asahi Kasei Kuraray Medical is a membrane with excellent performance and removal rates approaching the physiological sieving characteristics of the natural kidney.

Features

• Sharp cutoff curve
• Excellent clearance of low molecular-weight proteins
• Low albumin loss and significant decrease in β2-MG
• Good biocompatibility
• Less back-filtration of cytokine-inducing substances

Sharp cutoff curve

Like the natural kidney, Asahi Polysulfone APS achieves high elimination rates of molecules up to 66,000 Daltons.

Sieving coefficient	Excellent clearance of low molecular-weight proteins
(In-house data)	Adapted from: Permeability of a New Polysulfone (PS) High-flux (HX) Dialyzer APS-650 (Reference) A. Rockel. et al., Int. J Artif Organs, 21(10):1998. Abstracts, ESAO, Bologna, Italy, November 1998

Low albumin loss and significant decrease in β2-MG

Asahi Polysulfone APS has been designed to function like the glomerulus: albumin is preserved while low molecular-weight proteins such as β2-MG are eliminated.

Cliiclal evaluation of the new Polysulfone membrane dialyzer (APS) in long-team use

(Reference)
Sato Y. et al., Jpn J Artif Organs 26:858-864, 1997

Good biocompatibility

Preserving the natural flow of blood components

The hydrophilic gel layer on the APS membrane inner surface when wet is shown on the left. It appears softer than the other wet polysulfone inner surface shown on the right, because the hydrophilic gel layer retains water molecules, a major characteristic of the APS membrane. With its softer inner surface, APS is designed to cushion platelets and other blood components from activation caused by the blood-membrane interaction.

Surface of internal membrane with hydrophilic gel layer created with atomic force microscopy

The vertical axis is shown on a much larger scale than the horizontal plane for easier comparison between the two types of inner surface.

Little change in leukocytes and platelets during dialysis

(Clinical Data 1998)
M. Foret, et al., Agduc Grenoble. France

Low heparin requirements with APS

The minimum heparin dosage was determined by reducing the heparin administered in successive dialyses by 400 units (100U/hr x 4h) per session, and the minimum dosage was determined to be that at the session before the dialyzer fibers contained approximately 30% residual blood. With APS, the minimum heparin dosage* was lower than with any other polysulfone dialyzer.

Minimum heparin dosage during hemodialysis *Minimum heparin dosage (U/kg/hr) = constant heparin infusion rate (U/hr)/[(pre W(kg)+post W(kg))/2] pre W: pre-dialysis weight post W: post-dialysis weight (Reference) Terada, et al., The 44th Congress of Jpn. Soc. Dia. Ther, DP-1061, 1999

Less back-filtration of cytokine-inducing substances

The structure and composition of Asahi Polysulfone APS suppresses back-filtration of cytokine-inducing substances, making it ideal for hemodialysis, hemofiltration, and hemodiafiltration.

Pyrogen Retention by the Asahi Polysulfone Dialyzer APS-650 during in vitro Dialysis with Whole Human Donor Blood
Sylvia Linnenweber, Gerhard Lonnemann
Division of Nephrology, Medizinische Hochschule Hannover, Hannover Germany

(References)
Klingel R, et al., Blood Purif, 20:325-33, 2002
Mandolfo S, et al., Int. J. Artif. Organs, 29:949-55, 2006

For more information, please press the above CONTACT US button.