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Reagents for the Measurement of Glycated Albumin (GA) Lucica® GA-L

Characteristics of Glycated Albumin

POINT1 Serum albumin is a readily glycated protein.

Glycated albumin (GA) is a glycation product of serum albumin.

Located in blood and throughout the body, albumin is a protein that bonds easily with glucose.

Albumin glycates at four lysine (Lys) sites. 
  Pablo Vidal 13th Int. Sympo. Stockholm, June 1989

Albumin glycates at four lysine (Lys) sites.
Pablo Vidal, et al. 13th Int. Symposium on Column Liquid Chromatography, Stockholm, June 1989 

 

Glycated albumin changes markedly.

GA values are approximately 3 times larger than their corresponding glycated hemoglobin (HbA1c) values and reflect changes in blood glucose levels markedly.

Changes in glycated albumin (GA) and glycated hemoglobin (HbA1c) values during SU + α-GI treatment

Changes in glycated albumin (GA) and glycated hemoglobin (HbA1c) values during SU + α-GI treatment

Combination therapy with a sulfonylurea* (SU) and an α-glucosidase inhibitor** (α-GI) was administered to 16 outpatients with type 2 diabetes.

With the use of glycated albumin (GA) as an indicator, the dose of the sulfonylurea was adjusted to achieve effective treatment.

 

Mean patient data (n=16)
  Before treatment 12 weeks later
Blood glucose (mg/dl) 2 hours after breakfast 166±28 123±27
Serum IRI (μU/ml) 2 hours after breakfast 23.3±13.0 19.4±8.8
SU dose (mg) 64±35 48±31

*SU: gliclazide
**α-GI: acarbose or voglibose

Ryuzo Kawamori, Juntendo University School of Medicine
Diabetes 39:527-529 (1996)


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POINT2 Glycated albumin levels reflect more immediate blood glucose status.

Since the half-life of albumin is short, glycated albumin (GA) mainly reflects the average blood glucose value over the previous 2 weeks.

Relation of glycated albumin (GA) and glycated hemoglobin (HbA1c) with blood glucose levels in the past

 

Measurement of glycated albumin can confirm changes in blood glucose status 1 to 2 weeks after the commencement of treatment.
Blood glucose status can be more accurately assessed in a monthly interval with the measurement of glycated albumin than with the measurement of glycated hemoglobin.

GA rapidly confirms treatment efficacy. GA rapidly confirms treatment efficacy.

Shigeki Endo, Shizuoka Saiseikai General Hospital
Shizusai Ishi, 13(1): 23-35 (1997) (in Japanese)

 

 

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