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What's Glycated Albumin (GA)? 1st page

What's Glycated Albumin (GA)?

Glycation is the bonding of a sugar molecule, such as glucose, to a lipid or protein molecule, such as albumin. Thus, glycated albumin refers to albumin to which glucose has bonded.

Albumin is present not only in blood, but also in major organs and body fluids. Albumin serves to maintain cell shape and plays an important function in the distribution of hormones, nutrients and some drugs in the body.

The amount of glycated albumin decreases when blood glucose levels are low and increases when blood glucose levels are high.

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When is Glycated Albmin measured?

Glycated albumin is measured when diabetes therapy is initiated to determine medication regimens and doses and to assess overall therapy efficacy.

The following disorders can markedly alter albumin and hemoglobin life spans, potentially affecting measurement values.

  • Glycated albumin ··········nephrosis, cirrhosis, and thyroid functional disorder
  • Glycated hemoglobin ···anemia, renal failure, and cirrhosis

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Distinguishing between Glycated Hemoglobin and Glycated Albumin

Changes in glycated albumin and glycated hemoglobin values after the initiation of treatment were investigated. After the start of treatment, glycated albumin measurements showed improved values within approximately one week.

Glycated albumin is measured at the onset of therapy, and then every two to four weeks thereafter to adjust medication regimens. Glycated albumin provides a more rapid indication of treatment efficacy or disease state deterioration, than glycated hemoglobin.

Glycated hemoglobin is measured at initial assessment when no prior data on glycemic control are available, and then every one to two months once stable glycemic control has been achieved, to assess average blood glucose over an extended period of time.

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