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Serum albumin is a readily glycated protein. |
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Glycated albumin levels reflect more immediate blood glucose status. |
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Glycated albumin (GA) is a glycation product of serum albumin.
Located in blood and throughout the body, albumin is a protein that bonds easily with glucose. |
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| Albumin glycates at four lysine (Lys) sites. |
| Pablo Vidal, et al. 13th Int. Symposium on Column Liquid Chromatography, Stockholm, June 1989 |
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| The glycation rate of albumin to glucose is about 10 times higher than that of hemoglobin to glucose. |
| James F. Day, et al. Diabetes 29:524-527 (1980) |
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| GA values are approximately 3 times larger than their corresponding glycated hemoglobin (HbA1c) values and reflect changes in blood glucose levels markedly. |
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Changes in glycated albumin (GA) and glycated hemoglobin (HbA1c) values during SU + α-GI treatment |
Combination therapy with a sulfonylurea* (SU) and an α-glucosidase inhibitor** (α-GI) was administered to 16 outpatients with type 2 diabetes.
With the use of glycated albumin (GA) as an indicator, the dose of the sulfonylurea was adjusted to achieve effective treatment. |
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*SU: gliclazide
**α-GI: acarbose or voglibose
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| Ryuzo Kawamori, Juntendo University School of Medicine |
| Diabetes 39:527-529 (1996) |
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| Since the half-life of albumin is short, glycated albumin (GA) mainly reflects the average blood glucose value over the previous 2 weeks. |
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| Relative weighting of past blood glucose levels to a glycated albumin (GA) or glycated hemoglobin (HbA1c) value |
Kenji Shima, University of Tokushima School of Medicine
Adapted from Saishin Igaku, Vol.50, supplement (1995) (in Japanese) |
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| GA rapidly confirms treatment efficacy. |
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| Shigeki Endo, Shizuoka Saiseikai General Hospital |
| Shizusai Ishi, 13(1): 23-35 (1997) (in Japanese) |
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