热点话题

糖化白蛋白与糖尿病并发症之间的关系

在世界范围内，受糖尿病困扰的患者人数在逐年增加。恰当地控制血糖对于预防与糖尿病相关的并发症（例如，神经系统病变、肾病、视网膜病和大血管病变）至关重要。全球范围内对于糖化白蛋白与糖尿病并发症风险之间的关系均有报道。

✔ DCCT/EDIC Study ^1-2)
In case-cohort analyses (n=497), HbA1c and GA had similar associations with
Retinopathy and nephropathy. These associations were strengthened when both
Measures were considered together.²⁾

✔ ARIC Study ^3-4)
Over the course of two decade of following up on 11,104 participants, there were 1,096 new cases of coronary heart disease, 605 cases of ischemic stroke, 1,432 cases of heart failure, and 2,860 deaths. GA was associated with vascular outcomes and mortality.⁴⁾

✔ A five-year retrospective longitudinal study in Shanghai　⁵⁾
In this five-year retrospective longitudinal study (n=359), the presence of diabetic retinopathy (DR) at baseline, poor glycemic control, GA, and impaired renal function provided signs of DR progression in patients with type 2 diabetes mellitus.

References
1) Nathan DM, et l., Determining stability of stored samples retrospectively: the validation of glycated albumin, Clin Chem. 2011 Feb;57(2):286-90.
2) Nathan DM, et al., Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy,and cardiovascular outcomes in the DCCT/EDIC Study, Diabetes, 63(1): 282-290, 2014
3) Selvin E, et al., Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study, Lancet Diabetes Endocrinol. 2014 Apr;2(4):279-88.
4) Selvin E, et al., Fructosamine and glycated albumin and the risk of cardiovascular outcomes and death, circulation, 132(4): 269-277, 2015
5) Pan J, et al., Serum glycated albumin predicts the progression of diabetic retinopathy-a five year retrospective longitudinal study, J Diabetes
Complic, 28(6): 772-778, 2014

久山町研究（日本）

一项关于日本生活方式疾病的流行病学研究，即久山町研究表明，较高的糖化白蛋白和 HbA1c 值与糖尿病性视网膜病变的患病率增加有关。作为糖尿病性视网膜病变发病的可预测指标，糖化白蛋白和 HbA1c 的 AUC 值均高于 0.9。

通过空腹血糖、餐后两小时血糖、血红蛋白 A1c 和糖化白蛋白的数据分布（精确到十分位）得出糖尿病视网膜病变的患病率

比较空腹血糖、餐后两小时血糖、血红蛋白 A1c、糖化白蛋白和 1,5-脱水葡萄糖醇对于糖尿病性视网膜病变的判别能力。