Reagents for the Measurement of Myoinositol (MI) Lucica MI

Features of MI

normoglycemia

normoglycemia

hyperglycemia

hyperglycemia

further hyperglycemia

further hyperglycemia

When glucose levels are normal (normoglycemia), blood glucose and MI are almost completely reabsorbed back into the blood. However, when glucose levels are elevated (hyperglycemia), reabsorption of MI in the renal tubules is inhibited by glucose, so MI is excreted in the urine. With further hyperglycemia, glucose also cannot be completely reabsorbed by the kidney, and so is excreted in the urine (urinary glucose).

 

Kawazu S, et al: Jpn J Med Pharm Sci
52(6): 981-987, 2004


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(1) The method of MI measurement

The change in urinary MI (UMI) from before to after glucose load (ΔUMI) is used as an index.
UMI, unlike urinary glucose, is very stable for 3 days at room temperature and 2 weeks under refrigeration.

* Creatinine should be measured using the enzyme method.


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(2) ΔUMI reflects plasma glucose levels sfter glucose loading

After glucose loading, ΔUMI correlates well with glucose levels. In addition, ΔUMI after glucose loading offers a good indicator of hyperglycemic state that may be undetected by FPG.

×NGT ▲Pre-borderline type* □Borderline type ●DM

* Within the NGT group, those with a 1-h plasma glucose > 180mg/dL are difined as ‘pre-borderline type’.

Kawazu S, et al: Jpn J Med Pharm Sci
52(6): 981-987, 2004


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(3) Suitability of ΔUMI for detecting glucose intolerance

Δ UMI reflect the degree of glucose tolerance and increases in proportion to the degree of glucose intolerance. The best reference standard is <10mg/gCr.



Kawazu S, et al: Jpn J Med Pharm Sci
52(6): 981-987, 2004


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(4) Comparison of ΔUMI and other glycemic control markers

Compared with other simultaneously measured glycemic control markers, the detection rate of ΔUMI is superior for detecting not only diabetes mellitus (DM), but also impaired glucose tolerance (IGT) and pre-borderline-type individuals who show hyperglycemia after glucose loading.

group n Detection rate
ΔUMI HbA1c 1,5AG 2hUG*
>10mg/gCr >5.8% <14μg/dL >100mg/dL
DM 59 90% 66% 64% 80%
IGT 61 67% 21% 28% 44%
IFG 22 55% 14% 18% 36%
Pre-borderline type 41 61% 0% 24% 29%
NGT 179 11% 1% 7% 6%

IGT; impaired glucose tolerance
IFG; impaired fasting glucose

Kawazu S, et al: Jpn J Med Pharm Sci
52(6): 981-987, 2004 was changed

 

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