HOME > ルシカ® > ルシカ®GA-L2 > トピックス(GAと糖尿病合併症との関連)




わが国を代表する生活習慣病の疫学研究の一つである久山町研究において、GAや HbA1cが高値であるほど糖尿病網膜症の有病率が上昇しました。また、糖尿病網膜症出現の予測能は、GA、HbA1cともに0.9を超えるAUCを示しました。

【対象】 75 g 経口ブトウ糖負荷試験(OGTT)を実施した40-79歳の2681名
【方法】 空腹時血糖(FPG)、負荷後2時間血糖(2-hour PG)、HbA1c、GAの10分位別に糖尿病網膜症の有病率を算出し、各血糖関連指標における糖尿病網膜症出現に関してROC解析を実施しました。




Mukai N, et al. Thresholds of various glycemic measures for diagnosing diabetes based on
prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.
©2014 Mukai N, et al. ; licensee BioMed Central Ltd Creative Commons Attribution License





DCCT/EDIC Study 1-2)
In case-cohort analyses (n=497), HbA1c and GA had similar associations with
Retinopathy and nephropathy. These associations were strengthened when both
Measures were considered together.2)

ARIC Study 3-4)
Over the course of two decade of following up on 11,104 participants, there were 1,096 new cases of coronary heart disease, 605 cases of ischemic stroke, 1,432 cases of heart failure, and 2,860 deaths. GA was associated with vascular outcomes and mortality.4)


A five-year retrospective longitudinal study in Shanghai 5)
In this five-year retrospective longitudinal study (n=359), the presence of diabetic retinopathy (DR) at baseline, poor glycemic control, GA, and impaired renal function provided signs of DR progression in patients with type 2 diabetes mellitus.

In a multicenter, prospective cohort study( n = 499), followed up for 91 days in Beijing 6)
Logistic regression analysis showed that the change in GA at 28 days was the only predictor of good glycemic control in 176 patients with newly diagnosed diabetes (OR = 1.630, 95% CI 1.300-2.044, P < 0.001).

1) Nathan DM, et l., Determining stability of stored samples retrospectively: the validation of glycated albumin, Clin Chem. 2011 Feb;57(2):286-90.
2) Nathan DM, et al., Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy,and cardiovascular outcomes in the DCCT/EDIC Study, Diabetes, 63(1): 282-290, 2014
3) Selvin E, et al., Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study, Lancet Diabetes Endocrinol. 2014 Apr;2(4):279-88.
4) Selvin E, et al., Fructosamine and glycated albumin and the risk of cardiovascular outcomes and death, circulation, 132(4): 269-277, 2015
5) Pan J, et al., Serum glycated albumin predicts the progression of diabetic retinopathy-a five year retrospective longitudinal study, J Diabetes
Complic, 28(6): 772-778, 2014
6) Ren Q, et al., Search for clinical predictors of good glycemic control in patients starting or intensifying oral hypoglycemic pharmacological therapy: A multicenter prospective cohort study. J Diabetes Complications. 2020 Feb;34(2):107464.


2) 本試験において、旭化成ファーマ株式会社はGA測定キットを提供したが、試験の計画および実施、報告書の作成には関与していない。
3-4) 本試験において、旭化成ファーマ株式会社はGA測定キットを提供した。