Hemodialyzer / APS-HE: Hemodiafilter - Best suitability for HDF.

Performances

Clearance (in vitro)

APS-18HE APS-22HE
Clearances (mL/ min)1) Blood Flow (mL/min) 200 300 300 400 200 300 300 400
QF (mL/min) 0 0 75* 100* 0 0 75* 100*
Urea 198 278 290 365 199 284 293 374
Creatinine 198 274 292 365 199 281 295 374
Phosphate 189 248 269 325 192 260 279 340
Vitamin B12 150 174 208 246 162 192 224 265
Inulin 102 113 152 175 116 131 168 191
KoA (Urea)(mL/min)2) 1344 1559
KUF (mL/hr/mmHg (mL/hr/kPa))3) 86(647) 100(748)
Effectives Surface Area (m2) 1.8 2.2
Sieving Coefficient4) Inulin 1.0
β2-microglobulin 0.8
Myoglobin 0.5
Albumin < 0.001
APS-26HE
Clearances (mL/ min)1) Blood Flow (mL/min) 200 300 300 400
QF (mL/min) 0 0 75* 100*
Urea 200 289 296 381
Creatinine 200 288 297 381
Phosphate 196 269 285 352
Vitamin B12 171 206 237 283
Inulin 125 145 181 204
KoA (Urea)(mL/min)2) 2022
KUF (mL/hr/mmHg (mL/hr/kPa))3) 115(860)
Effectives Surface Area (m2) 2.6
Sieving Coefficient4) Inulin 1.0
β2-microglobulin 0.8
Myoglobin 0.5
Albumin < 0.001

Conditions:
1) Clearances: QD=500 mL/min, * Post-dilution HDF
2) KoA: QB=300mL/min, QD=500mL/min, QF=0mL/min
3) KUF: Measured with bovine blood, TP=60±5g/L, Hct=32±3%, QB=300mL/min
4) Sieving Coefficient: bovine plasma, TP=60±5g/L
EN ISO 8637-1:2020

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