What is therapeutic plasmapheresis?

Therapeutic plasmapheresis is an extracorporeal blood purification technique designed for the removal of pathogenic substances from the plasma of patients. Examples of these substances include pathogenic autoantibodies, immune complexes, cryoglobulins and cholesterol-containing lipoproteins.

Possibilities of Plasma Apheresis

Removal of antibodies

  • Alloantibodies
  • Autoantibodies
  • Immune Complexes

Removal of excessive or abnormal substances

  • Paraproteins
  • Cholesterol in Hypercholesterolaemia

Removal of toxins

  • Protein-bound Drugs / Toxins
  • Mushroom Poisons

Modalities of therapeutic plasmapheresis

Therapeutic plasmapheresis includes the following three modalities.

  • Plasma Exchange (PE)
  • Double Filtration Plasmapheresis (DFPP)
  • Immunoadsorption (IA) / Plasma Adsorption (PA)

Mechanism of membrane plasma separation

Plasma and proteins pass through the membrane but the pores are small and cellular components cannot pass across the membrane.

Plasma and pathogenic substances in the plasma can be discarded or purified and returned to the patient.

Applied diseases of plasmapheresis

Please see below for conditions for which Plasmapheresis is indicated.

Applied diseases

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