Concentration and Purification After Cultivation or Fermentation

Solving challenges in concentration and purification processes after cultivation and fermentation. Microza® achieves high recovery rates, efficiency, and labor savings, and also contributes to waste reduction. Its features and case studies in the food industry are introduced.

Improved Productivity, Stable Quality, and Cost Efficiency

The concentration and purification processes after cultivation and fermentation are complex and involve multiple challenges such as cost, labor, and quality control. The Microza® hollow fiber membrane solution enables high recovery rates and low-cost operation, achieving efficient and stable processes. Please see case studies in the food industry.

Comprehensive Solutions for Post-Cultivation and Fermentation Issues

The following challenges may arise in concentration and purification processes after cultivation and fermentation:

Frequent loss of enzymes during concentration and purification leads to increased raw material costs.
Use and disposal of filter aids increase operating costs.
Frequent maintenance required for each filtration cycle causes shortages in manpower and time.

Microza® addresses these challenges with the following features:

Low-Cost Operation
No filter aids required, reducing purchase and disposal costs. High-efficiency filtration is achieved even at low linear velocity, lowering energy costs.
Improved Quality and Yield
Stable separation performance with hollow fiber membranes minimizes leakage of target substances and reduces the burden on subsequent purification steps.
Automation and Labor Saving
Membranes and system design with excellent durability and chemical resistance reduce cleaning and maintenance workload, alleviating manual labor.
Reduced Risk of Product Deterioration
Low linear velocity separation reduces physical stress on cells and products, protecting the quality of precision fermentation products.

With these features, Microza® solves complex issues in post-cultivation and fermentation processes and supports efficient and stable process operation.

Efficiency and Environmental Consideration Beyond Other Filtration Methods and Centrifugation

Compared to other filtration methods and centrifugation, Microza® offers advantages in the following aspects:

Reduced Workload and Labor Saving: Simplified operations through automated systems.
Cost Reduction: No filter aids required and improved energy efficiency reduce operating costs.
High-Quality, Low-Stress Separation: Gentle handling of cells and enzymes under low linear velocity conditions.
Large Membrane Area: The hollow fiber structure offers a high membrane area per unit volume, enabling compact systems with low power consumption.
Scalability: System configurations can be designed per membrane module. Specialized staff support scalable system design.

Extensive Product Lineup and Scalable Capability

Requirements for membrane technology vary greatly depending on production scale and target substances. In the food and pharmaceutical industries, ensuring sanitary conditions and smooth scale-up from research to commercial production are especially important. Microza® meets these diverse needs with a lineup of over 200 types of MF and UF membranes. In particular, membranes with large hollow fiber inner diameters suitable for concentration applications are available to meet customer needs.

View Microza® Product Lineup

Please feel free to contact us. Full support is provided from introduction to operation.

Microza® solutions go beyond simple product supply. Comprehensive support is provided, including resource recovery services for filtration residues, operational planning through sample analysis, post-installation operation and maintenance, and advice on regulatory compliance. For companies aiming to expand contract business, we also answer questions about not only hollow fiber membranes but also equipment and regulatory compliance in the relevant industry.