- Pharmaceuticals
- Separation technology
Renovation in Biopharmaceuticals Production and Productivity Improvement for Objectives (Antibodies, Proteins, Vaccines, Enzymes, etc.) based on Our Advanced Technologies
Microza responds to various challenges in pharmaceuticals
Increase yield of antibodies in separation process from
perfusion cultures of animal cells
Increase yield of proteins
in separation process from cultures solutions of E. Coli, yeast, ect.
Increase the yields
in the concentration and purification processes of vaccines and virus
Want to increase the yields
in the concentration and desalination processes of enzymes for industrial uses
Why Microza?
High productivity and filtration stability
The original membrane technology of Microza enables precise control of pore structures on the membrane, realizing high yields of target materials and stable filtration in the upstream and downstream membrane filtration separation processes of biopharmaceutical production.
Extensive product lineup
A total of four membrane materials are available: PVDF and PE for MF, and PAN and PS for UF.
High antibody permeability
Polyvinylidene difluoride (PVDF) membrane demonstrates high antibody permeability in perfusion culture production by the combination of material properties (high durability and high sanitation as it allows steam sterilization) and fine pore structures (uniformity and communication property) on the membrane.
Low protein adsorption at separation from culture medium
Polyethylene (PE) membrane can separate proteins from culture medium without adsorbing them by its material properties (high durability and hydrophilicity) and the fine pore structures (uniformity and void ratio) on the membrane.
High productivity of the protein concentration process with PAN membrane
Polyacrylonitrile (PAN) membrane demonstrates excellent separation performance of enzymes in the concentration and purification processes by the combination of material properties (high hydrophilicity and low adsorption) and the fine pore structure (uniformity) on the membrane.
Our Products
MF membrane; UMP/UJP Series
MF membranes specialized for biopharmaceutical applications. Achieves long-term perfusion cell culture under high cell density.
UF membrane; AP and SP series
UF membranes with excellent sanitary properties and widely used in food, pharmaceutical, and biotechnology applications.
MF membrane; P Series
MF membranes made of polyethylene material and applicable to a wide range of pH.
Applications
- Upstream: UMP and UJP series provide especially high antibody recovery rates and filtration stability in continuous culture production of monoclonal antibodies.
- Downstream: PNA series provides high protein recovery rates in batch culture production of vaccines and protein pharmaceuticals.
Examples of Microza application in upstream and downstream processes
